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  • Steven Skipper posted an update 1 year, 5 months ago

    Additionally, five dogs in this group of 17 had elevated ALT before taking rosiglitazone (three with grade 1 and two with grade 3 elevations) and interestingly, these ALT elevations remained static on the combination of rosiglitazone (dose range 3.5�C4.5 mg/m2) and carboplatin. In conclusion, rosiglitazone is orally absorbed and well tolerated in the dog in combination with carboplatin. The maximally tolerated dose appears to be 6 mg/m2, and hepatotoxicity appears to be the Selleckchem Everolimus dose-limiting toxicity. Whether this is the appropriate biologically effective dose requires further investigation. Liver function should be routinely monitored in patients taking rosiglitazone and caution should be exercised when considering use of this drug in patients with pre-existing abnormal hepatic function or in combining rosiglitazone with other known hepatotoxic drugs. Ultimately, further study is required to evaluate the safety of rosiglitazone in patients with abnormal liver function, to determine the biologically effective dose and to determine appropriate tumor types responsive to this combination. The authors would like to thank Drs. Danielle O’Brien, Steve Shaw and Anna Szivek for their assistance in recruiting patients for this study. They would also like to thank Beth Bishop, Virginia Canaan, Randy Gordon, Dakin Oliver and Kriste Sein for their assistance with pharmacokinetic blood collection. This study was paid for in part by the University of California, Davis Center for Companion Animal Health Grant # 2007-45-R, the Toni Wiebe Memorial Research Fund (TAG) and the Joe Rico Cancer Research Fund (SDAF). ””Fascin-1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin-1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin-1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin-1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin-1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin-1 may represent a new strategy for the treatment of canine melanoma. ""Vineatrol?30 is a grapevine-shoot extract, which contains resveratrol as well as considerable amounts of so-called resveratrol oligomers such as hopeaphenol and r2-viniferin.