Steven Skipper posted an update 5 months ago
?2A�CC). In the group of proteinuria 3500?mg/L (N?=?6), the five-yr patient survival was 85.8%, 62.6%, 41.7%, and 80%, respectively (p?<?0.001), five-yr death-censored graft survival was 76.9%, 36.8%, 0%, and 50%, respectively (p?<?0.001), and the five-yr overall survival (including death) was 68.7%, 24.7%, 10.3%, and 41.7%, respectively (p?<?0.001). To systematically assess the relationship between proteinuria and survival, we performed a ROC curve analysis. The Selleck Venetoclax first ROC curve analysis for patient survival using quantitative value only showed an area under the curve (AUC) of 0.557, p?=?0.39, N?=?311. The second ROC curve analysis for patient survival using imputed values as well showed an AUC of 0.577, p?=?0.13, N?=?528. There was no significant impact on patient survival. We found a significant relationship between proteinuria at conversion and death-censored graft survival with an AUC of 0.728 (p?<?0.001, N?=?311, Fig.?3) and a cutoff value of 268?mg/L urinary protein (sensitivity 61.4%, specificity 83.9%, positive predictive value [PPV] 90.6%, and negative predictive value [NPV] 46.1%). Considering imputed values as well, the AUC was 0.71 (p?<?0.001, N?=?524) and the cutoff value was 151?mg/L (sensitivity 66.7%, specificity 72.9%, PPV 91.1%, NPV 34.4%, N?=?528). As shown in Fig.?4A, already modest proteinuria >268?mg/L had a strong impact on graft failure. The five-yr death-censored graft survival was 79.7% in patients below and 34.8% in patients above the cutoff value of 268?mg/L. Using imputed values for the cutoff value of 151?mg/L, five-yr death-censored graft survival was 81.1% (151?mg/L), respectively (p?<?0.001, Fig.?4B). When performing a ROC curve analysis for overall survival (including death), we found a cutoff of 151 mg/L (p < 0.001, AUC 0.699, sensitivity 67.1%, specificity 72.3%, PPV 87.8%, NPV 42.6%, N = 311). The overall five-yr overall survival (including death) was 72.3% vs. 33.6% (p < 0.001, Fig.?5A). The same cutoff was calculated in the second ROC curve analysis using imputed values (AUC 0.692, p < 0.001, sensitivity 61.8%, specificity 74.3%, PPV 86.5%, NPV 42.2%, N = 528). The overall five-yr overall survival (including death) was 72.7% vs. 33.7% (p < 0.001, Fig.?5B) for this imputed cutoff. Lastly, we performed a Cox proportional hazard analysis on overall survival (including death) (Table?2). There was a 1.556-fold (CI: 1.252�C1.934, p?<?0.001) higher risk of graft loss or death per 1000?mg/L urinary protein concentration at conversion. Similarly, creatinine at conversion was associated with an increasing risk of 2.898 per mg/dL (CI: 2.233�C3.761, p?<?0.001). As expected, age at transplantation increased the risk of graft loss and death (HR 1.031 per year; CI: 1.010�C1.053, p?=?0.004).
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This is my winter look. I am a 13 year old "cockabishit" born in Calgary and now happily living on the Coast the past 10 years. I really dislike baths, people on skateboards, bikes and other things with wheels...its just wrong! My favorite things are mikey, my couch, beggin strips and walks with my family. Visit my profile to see my after picture!