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  • Steven Skipper posted an update 11 months, 3 weeks ago

    PTDM was defined as a need for anti-diabetic therapy in an RTR without a history of diabetes prior to transplantation. Analysis of the risk factors for development of PTDM was performed with respect Dabrafenib ic50 to pre-transplant dialysis modality. A total of 137 (6.8%) patients developed PTDM; 7% in the hemodialysis group and 6.5% in the peritoneal dialysis (PD) group (p?=?0.85). In the multivariate analysis, age (p?<?0.001), body mass index (BMI) (p?<?0.001), use of tacrolimus (p?=?0.002), and rejection episodes (p?<?0.001) were identified as independent risk factors for development of PTDM. Patients in the PD group were younger (p?=?0.004), had lower BMI (p?=?0.07), and were less likely to have a history of hepatitis C (p?=?0.007) and autosomal dominant polycystic kidney disease (p?=?0.07). Adjustment for these variables did not modify the results. The results of this study suggest that pre-transplant dialysis modality does not have an impact on the subsequent development of PTDM in RTRs. ""da Silva Santos PS, Coracin FL, Barros JCA, Dulley FL, Nunes FD, Magalh?es MG. Impact of oral care prior to HSCT on the severity and clinical outcomes of oral mucositis. Clin Transplant 2011: 25: 325�C328. ? 2010 John Wiley & Sons A/S. Abstract:? Patients who undergo hematopoietic stem cell transplantation (HSCT) frequently experience gastrointestinal toxicity as a result of their preparative regimen. The most frequent manifestation is oral mucositis (OM) and diarrhea. We studied the effects of oral care prior to HSCT on the severity of OM. Seventy patients suffering from hematologic malignancies who had undergone HSCT were divided into two groups (35 patients �C Study Group [SG] and 35 �C Control Group [CG]), and the severity of OM was evaluated by two calibrated dentists, using the WHO scale. The patients from the SG received oral care prior to HSCT and those from CG did not receive any dental care. The results showed no differences (p?=?0.20) in the incidence or severity of OM among the groups. However, patients from the SG presented a shorter time elapsed (p?<?0.001) when compared with the CG (median: 10 vs. 20?d). Our results show the importance of simple, inexpensive preventive intervention to control the time elapsed of OM, which reduces morbidity and, as a consequence, the cost of the treatment. ""Ferreira AC, Nolasco F, Carvalho D, Sampaio S, Baptista A, Pessegueiro P, Monteiro E, Mour?o L, Barroso E. Impact of RIFLE classification in liver transplantation. Clin Transplant 2010: 24: 394�C400. ? 2009 John Wiley & Sons A/S. Abstract:? Acute renal failure (ARF) is common after orthotopic liver transplantation (OLT). The aim of this study was to evaluate the prognostic value of RIFLE classification in the development of CKD, hemodialysis requirement, and mortality.