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  • Benny Miles posted an update 3 years, 1 month ago

    [13] A study of 245 PD patients in which those with depression and those without depression were compared, argues for PD depression to be more likely to be due to neuropathological changes in the brain than to environmental and psychological TAK-632 factors.[2] Depression is often not picked up in many patients as physicians tend to ignore anxiety and depression in older patients, concentrating instead on physical complaints. Many older patients are also reluctant to talk about their feelings or deny feeling sad or depressed. Clinicians must be sensitive to other signs, including worries about being a burden, feelings of worthlessness, losing interest in pleasurable activities, social withdrawal, and isolation (reluctance to be with friends, engage in activities, or leave home). Many of these symptoms, especially social withdrawal, may be dismissed as the natural consequences of reduced physical mobility and speech impairment associated with the disease. Another reason for missed diagnosis is that depression in PD is not straight-forward diagnosis because several clinical features of depression and PD overlap. As a result depression in PD is poorly recognized in clinical practice and depressive symptoms are Silmitasertib solubility dmso frequently missed. Depressive symptoms make dealing with PD more difficult and create a vicious cycle that impairs quality-of-life. Health-related quality-of-life is the most important outcome of health care and a main predictor of mortality and morbidity.[6,7,14,15,16] It is a critical measure in health care as it incorporates the patients�� own perspective of their health. Non motor symptoms have now been recognized as the major contributors to poor QOL; in particular neuro-psychiatric symptoms of which depression is the most common entity. The current study aims to find out the correlation between depression and the health-related quality-of-life (HRQOL) in patients with PD. MATERIALS AND METHODS The study aims to determine the correlation selleck between depression, gender, duration, and stage of the illness in patients of PD with the different domains of HR-QOL. The study was done on a cohort of patients attending a specialty PD clinic in a tertiary referral hospital. The clinic is a multi-disciplinary facility, exclusively for movement disorders with a team comprising Neurologists, Psychiatrist, Physiatrist, Speech and Swallow therapist, and Dietician. A sample of 65 consecutive patients diagnosed to have Idiopathic PD attending the specialty Parkinson’s Clinic were assessed by a psychiatrist as part of the treatment protocol. The sample comprised of 45 males and 20 females with a mean age of 60 years. Patients with mini mental status examination scoring of <27 were excluded from the study.[17] The demographic and other clinical data were collected from the patients clinical records.